R+D

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EMPIREO commitment to research aimed at creation of revolutionary new methods of detection.

Our team has extensive experience in basic-clinical research as well as in detection of biomolecules and markers of different pathologies.

EMPIREO is a signatory of the Cosce proposal for transparency on the use of animals in scientific experimentation in Spain.

This work is taking shape in numerous publications in various international journals:

Research team developed EMPIREO continuous research activity reflected in publication of numerous articles in international journals, which are detailed below. 

  • Álvarez E, Toledano V, Morilla F, Hernández-Jiménez E, Cubillos-Zapata C, Varela-Serrano A, Casas-Martín J, Avendaño-Ortiz J, Aguirre LA, Arnalich F, Maroun-Eid C, Martín-Quirós A, Quintana Díaz M, López-Collazo E. A System Dynamics Model to Predict the Human Monocyte Response to Endotoxins. Front Immunol. 2017 8:915.doi: 10.3389/fimmu.2017.00915.

  • Hernández-Jiménez E, Cubillos-Zapata C, Toledano V, Pérez de Diego R, Fernández-Navarro I, Casitas R, Carpio C, Casas-Martín J, Valentín J, Varela-Serrano A, Avendaño-Ortiz J, Alvarez E, Aguirre LA, Pérez-Martínez A, De Miguel MP, Belda-Iniesta C, García-Río F, López-Collazo E. Monocytes inhibit NK activity via TGF-β in patients with obstructive sleep apnoea. Eur Respir J. 2017 49(6). pii: 1602456. doi: 10.1183/13993003.02456-2016.

  • Toledano V, Hernández-Jiménez E, Cubillos-Zapata C, Flandez M, Álvarez E, Varela-Serrano A, Cantero R, Valles G, García-Rio F, López-Collazo E. Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100. Mediators Inflamm. 2015:942517. doi: 10.1155/2015/942517.
  • Fernández-Ruiz I, Arnalich F, Cubillos-Zapata C, Hernández-Jiménez E, Moreno-González R, Toledano V, Fernández-Velasco M, Vallejo-Cremades MT, Esteban-Burgos L, de Diego RP, Llamas-Matias MA, García-Arumi E, Martí R, Boscá L, Andreu AL, López-Sendón JL, López-Collazo E. (2014) Mitochondrial DAMPs induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction. PLoS One. 29(5):e95073. doi: 10.1371/journal.pone.0095073. You can download the pdf of the article here.
  • del Campo R, Martínez E, del Fresno C, Alenda R, Gómez-Piña V, Fernández-Ruíz I, Siliceo M, Jurado T, Toledano V, Arnalich F, García-Río F, López-Collazo E. (2011) Translocated LPS might cause endotoxin tolerance in circulating monocytes of cystic fibrosis patients. PLoS One. 6(12):e29577. doi: 10.1371/journal.pone.0029577. You can download the pdf of the article here.
  • del Fresno C, García-Rio F, Gómez-Piña V, Soares-Schanoski A, Fernández-Ruíz I, Jurado T, Kajiji T, Shu C, Marín E, Gutierrez del Arroyo A, Prados C, Arnalich F, Fuentes-Prior P, Biswas SK, López-Collazo E. (2009) Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients. J Immunol. 182(10):6494-507. doi: 10.4049/jimmunol.0803350. You can download the pdf of the article here.
  • del Fresno C, Gómez-Piña V, Lores V, Soares-Schanoski A, Fernández-Ruiz I, Rojo B, Alvarez-Sala R, Caballero-Garrido E, García F, Veliz T, Arnalich F, Fuentes-Prior P, García-Río F, López-Collazo E. (2008) Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: down-regulation of TREM-1 as putative underlying mechanism. PLoS One. 3(7):e2667. doi: 10.1371/journal.pone.0002667. You can download the pdf of the article here.
  • Gómez-Piña, V., Soares-Schanoski, A., Rodríguez-Rojas, A., del Fresno, C., García, F., Vallejo-Cremades, M., Arnalich, F., Fuentes-Prior, P., López-Collazo, E. (2007). Metalloproteinases shed TREM-1 ectodomain from LPS-stimulated human monocytes. J Immunol. 179(6):4065-73. DOI: https://doi.org/10.4049/jimmunol.179.6.4065. You can download the pdf of the article here. In this study, we first described the mechanism by which a soluble factor that is involved in systemic infections is generated.
  • Soares-Schanoski, A., Gómez-Piña, V., del Fresno, C., Rodríguez-Rojas, A., García, F., Glaría, A., Sánchez, M., Vallejo-Cremades, M., Baos, R., Fuentes-Prior, P., Arnalich, F., López-Collazo, E. (2007). 6-Methylprednisolone down-regulates IRAK-M in human and murine osteoclasts and boosts bone-resorbing activity: A putative mechanism for corticoid-induced osteoporosis. J Leukoc Biol. 82(3):700-9. DOI:10.1189/jlb.1106673. You can download the pdf of the article here. Our research team contributed to the description of the mechanism of various drugs on the type of steroid osteoporosis.
  • del Fresno, C., Soler-Rangel, L., Soares-Schanoski, A., Gómez-Piña, V., González-León, M., Gómez-García, L., Mendoza-Barberá, E., Rodríguez-Rojas, A., García, F., Fuentes-Prior, P., Arnalich, F., López-Collazo, E. (2007). Inflammatory responses associated with acute coronary síndrome up-regulate IRAK-M and induce endotoxin tolerance in circulating monocytes. Journal of Endotoxin Research. J Endotoxin Res.13(1):39-52. DOI:10.1177/0968051907078623. You can download the pdf of the article here. This paper describes how the molecule IRAK- M is involved in the poor response seen in patients with acute coronary syndromes.
  • González-León MC, Soares-Schanoski A, del Fresno C, Cimadevila A, Goméz-Piña V, Mendoza-Barberá E, García F, Marín E, Arnalich F, Fuentes-Prior P, López-Collazo E. (2006) Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner. J Endotoxin Res. 12(5):296-306. DOI:10.1179/096805106X118843. You can download the pdf of the article here. Research team EMPIREO described a mechanism by which average oxide molecule in inflammatory response. This molecule is important in inflammatory processes, especially in cardiac pathologies. This work was very important in the beginning of research activity EMPIREO. Allowed to characterize how tumor cells slow the response of the innate immune system.
  • del Fresno C, Otero K, Gómez-García L, González-León MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, García F, Arnalich F, López-Collazo E. (2005) Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4. You can download the pdf of the article here.

To access these publications may do so through website of the American Institute of Health (NIH) in www.pubmed.com, by searching for “Del Fresno García Lopez-Collazo” surnames of our research team.

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